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2024 Vol.4, Issue 2 Preview Page

Original Articles

Tetrodotoxin: Toxicity, Analytical Method and Safety Management

테트로도톡신: 독성, 분석법 및 관리 동향

Youngjin Kim1
,
Kanghyun Lee1
,
Namhyun Kim1
,
Youn-Jung Kim234
,
Jungsuk Lee1
,
Young-Seok Han1*
김 영진1
,
이 강현1
,
김 남현1
,
김 연정234
,
이 정석1
,
한 영석1*
1NEB Co., Seoul 08504, Korea
2Department of Marine Science, College of Natural Sciences, Incheon National University, Incheon 22012, Korea
3Research Institute of Basic Sciences, Incheon National University, Incheon 22012, Korea
4Yellow Sea Research Institute, Incheon 22012, Korea
1㈜엔이비
2인천대학교 해양학과
3인천대학교 기초과학연구소
4인천대학교 황해연구소
*Corresponding Author
31 December 2024. pp. 51-61
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Abstract

Tetrodotoxin (TTX) is a neurotoxin that blocks nerve signal transmission, leading to potent paralytic effects. It is primarily found in various marine organisms such as pufferfish, gastropods, and some cephalopods. TTX contamination poses a serious health risk due to potential seafood poisoning, necessitating appropriate safety management measures. This study provides a comprehensive review of TTX's toxicological characteristics, analytical methods, and current safety management trends. Specifically, a comparative evaluation of various analytical techniques, including ELISA and LC-MS/MS, was conducted. Current safety standards for TTX are based on the acute reference dose (ARfD) set by EFSA and the minimum lethal dose (MLD) regulations in Japan. However, the spread of TTX-producing microalgae due to climate change highlights the need for a re-evaluation of existing standards and the establishment of additional exposure safety criteria. This study offers a scientific basis for strengthening TTX monitoring systems in seafood, which can serve as foundational data for future regulatory and policy development.

Keywords
Acute Toxicity Assessment
Human Exposure Safety Standards
Pufferfish
Tetrodotoxin
Toxic Equivalency Factor

테트로도톡신(TTX)은 신경 신호 전달을 차단하여 강력한 마비 효과를 유발하는 신경독소로, 주로 복어, 복족류 및 일부 두족류 등 다양한 해양 생물에서 발견된다. TTX 오염은 해산물 섭취 시 중독을 유발할 수 있어 인체 건강에 심각한 위협을 가하며, 이에 대한 적절한 안전 관리가 요구된다. 본 연구에서는 TTX의 독성 특성과 분석 방법 및 최신 안전 관리 동향을 종합적으로 조사하였으며 ELISA, LC-MS/MS 등 다양한 분석 기법을 비교 평가하였다. 현재 TTX 관련 안전 기준은 EFSA에서 제시한 급성독성참고치와 일본의 최소치사량 규제를 기반으로 하고 있다. 그러나 기후 변화로 인해 TTX 생성 미세조류의 출현이 증가하면서 기존 기준의 재평가와 추가적인 노출 안전 기준 설정의 필요성이 커지고 있다. 본 연구는 해산물의 TTX 모니터링 체계 강화를 위한 과학적 근거를 제시하며, 향후 일관된 규제와 정책 수립에 기초 자료로 활용될 수 있다.

키워드
급성독성평가
독성등가계수
복어
인체노출안전기준
테트로도톡신
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Information
  • Publisher :The Korean Society of Phycology
  • Publisher(Ko) :한국조류학회
  • Journal Title :Aquatic Nature
  • Journal Title(Ko) :수생생물
  • Volume : 4
  • No :2
  • Pages :51-61
  • Received Date : 2024-11-20
  • Revised Date : 2024-12-13
  • Accepted Date : 2024-12-13
  • DOI :https://doi.org/10.23135/an.2024.4.2.2
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